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The GSH/GSSG ratio was lower in diamide-treated hearts, and 4-ClDzp blunted the increase in GSSG seen with diamide alone

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Majority of the side effects does not result in serious or long term consequence since they can be managed by selecting an alternative or careful formulation-design and/or dosage regimen

Raghav K, Liu S, Overman MJ, Willett AF, Knafl M, Fu SC, Malpica A, Prasad S, Royal RE, Scally CP, Mansfield PF, Wistuba II, Futreal AP, Maru DM, Solis Soto LM, Parra Cuentas ER, Chen H, Villalobos P, Verma A, Mahvash A, Hwu P, Cortazar P, McKenna E, Yun C, Dervin S, Schulze K, Darbonne WC, Morani AC, Kopetz S , Fournier KF, Woodman SE, Yao JC, Varadhachary GR, Halperin DM

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Used for thousands of years for pain and sedation, opioids first became commonly prescribed after new standards and regulations of pain management were established by the United States in 2000