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Start with a low, welldocumented dose and maintain consistent use for at least eight weeks before judging

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Starkebaum, G

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A: Alternatives to estradiol patches include FDA-approved transdermal gels and sprays, oral estradiol (with a different clot-risk profile), vaginal estrogen preparations for genitourinary symptoms, and compounded transdermal estradiol creams from PCAB-accredited pharmacies