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HICA is a -hydroxy-aminoacid and a leucine metabolite, which is produced by Lactobacillus species and also found in human muscle and connective tissues [45][47]

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Postmortem and imaging studies have revealed electron transport chain defects and impaired pyruvate dehydrogenase activity in ASD brains, with regional reductions in Complex I availability and non-ETC enzymes such as aconitase and PDH

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