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Under normal circumstances, Nrf2 is sequestered in the cytosol by the action of Kelch-like ECH-associated protein 1 (Keap1) which functions as an adaptor protein for the Cullin 3 (Cul3) containing E3 ubiquitin ligase enzyme
Most emissions of PAHs derive from human sources, i.e., fossil fuels pyrolysis, incomplete combustion, and burning of biomass [22]
It is not approved for medical, diagnostic, therapeutic, or veterinary use
doi: 10.3390/ijms21041186
Critical unresolved issues include identifying the molecular switches that govern the transition of autophagy from an anti- to a pro-ferroptotic state, elucidating subtype-specific differences in crosstalk mechanisms, and clarifying the molecular basis underlying proteins such as COX7A1 to exhibit opposing functions
Kim H, et al
