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at 1-800-633-9110 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch Drug Interactions Hepatic enzyme-inducing drugs (e.g., phenytoin, carbamazepine, phenobarbital, primidone, rifampin) can increase valproate clearance, while enzyme inhibitors (e.g., felbamate) can decrease valproate clearance

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10.1371/journal.pone.0051586 PLoS One 41 ShulyakovaN.AndreazzaA

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