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Biliary infection, especially by Escherichia coli, is another predisposing condition, since the microbe produces -glucuronidase, phospholipase A1, and conjugated bile acid hydrolase

Small intestinal transit time

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"Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy." J Clin Oncol 31(20): 2627-2633

In addition, the accumulation of acylcarnitine in the pathological state of the liver leads to insulin resistance, which further aggravates the development of liver diseases and results in a vicious cycle [211]

Another hypothesis relates increased gastrointestinal permeability, probably mediated by the immune system, with ASD onset (Navarro et al., 2015)