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In the last decades, IGF-1 has been implicated in many physiological actions, among others: tissue growth and development, proliferative, lipid metabolism, pro-survival/anti-aging, anti-inflammatory, anabolic, and antioxidant with neuro- and hepatoprotective properties [105116]

Frey II, a pioneer in intranasal central nervous system (CNS) delivery and adjunct professor at the University of Minnesota, explained it perfectly: We proved you could noninvasively deliver stem cells to the brain from the nose

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Thus, TB-500 is one of the active fragments of that protein

But optimal

PMID 10714245