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Elevated phosphorylation and aggregation of Tau are widely considered pathological hallmarks in AD (Wegmann et al., 2021)

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Endocrine dysregulation Spermatogenesis is tightly regulated by the HPT axis, involving hormones such as gonadotropin-releasing hormone(GnRH), LH, and FSH [135]

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Thus, P62 is an anti-inflammatory tumor suppressor that acts through the modulation of metabolism in the tumor stroma ( The Late Stage During early stages of transformation, tumor cells acquire gain-of-function mutations in oncogenes or loss-of-function mutations in tumor suppressor genes that cause excessive proliferation and anti-apoptosis