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While this route requires the peptide to cross the blood-brain barrier to reach CNS targets, the BBB is actually compromised in active MS lesions, which paradoxically may improve drug penetration at the sites where treatment is most needed

It may reduce solubility and stability

For the adults 60, the people who were homozygous for one of the polymorphisms (31% of the population studied) had average MMA levels of 420 nmol/l

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