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Whilst 510% of patients taking VPA may develop a transient alanine transaminase rise, numerous cases of acute liver injury presenting with jaundice and progression to fatal liver failure have been reported, with most cases occurring within the first 6 months of treatment

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For example, polylactic acid-glycolic acid copolymer (PLGA) nanoparticles can extend the drug release cycle to 72 hours

Glucose-lowering drugs have also shown good, stacked effects in patients who do not have good response with one drug alone