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The threshold increase is precautionary

Audo R, Sanchez P, Rivire B, Mielle J, Tan J, Lukas C, et al

The active site of each monomer contains a hydrophobic interior pocket and a large surface-exposed pocket, an architecture that accommodates the wide substrate specificity of DPP1 (34, 3942)
When the body doesnt have enough iron, all sorts of problems occurincluding hair loss and hair thinning

Refrigeration is preferred because it minimizes unnecessary freezethaw cycles during routine handling
