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In addition, chronic accumulation of fumarate by deletion of fumarate hydratase (FH) led to the formation of succinic GSH, a covalent adduct of fumarate and GSH, which correlated with persistent oxidative stress and cellular senescence in renal cells (121)
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Among the mechanisms discussed for the translocation of LPS in metabolic diseases are (i) a leaky gut [146]
doi: 10.1016/j.clindermatol.2021.08.021 134 SkovJ
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