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Targeting Nrf2 for ferroptosis-based therapy: Implications for overcoming ferroptosis evasion and therapy resistance in cancer

Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z, et al

Piperine, another natural compound, selectively induces mitochondrial apoptosis in A549 cells by activating Bax and caspases while sparing normal fibroblasts, demonstrating its potential as a selective chemotherapeutic agent (Lin et al

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The mobile phase consisted of phase A (0.1% formic acid in water) and phase B (0.1% formic acid in acetonitrile)

Selenium: This mineral is a key component of glutathione peroxidase, the enzyme that uses glutathione to neutralize hydrogen peroxide and other free radicals