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Theoretical concerns include excessive NAD+ elevation in individuals with preexisting metabolic disorders or mitochondrial dysfunction

2017 doi: 10.1152/ajpcell.00139.2017

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Although methylfolate and methylcobalamin do work together within the methylation cycle, tolerating one does not guarantee youll tolerate the othereven though many healthcare professionals suggest otherwise

10.2147/HP.S202775 131 SongQ.ChenY.WangJ.HaoL.HuangC.GriffithsA.et al (2020)
