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Preclinical research shows an excellent safety profile with no lethal dose identified in animal studies at doses far exceeding human protocols

Since the discovery of the HGF/c-Met pathway in the mid-1980s, c-Met has attracted significant attention as an anticancer target with several agents have been marketed including Tepotinib [7,8,9], Altiratinib [10], Capmatinib [11], Savolitinib [12, 13], and the ALK/c-Met inhibitor Crizotinib [14], and the initial results are encouraging

Bilirubin and redox stress in age-related brain diseases

(61) investigated GD2-targeted CAR-T cells (GD2-CAR-T) against SCLC cell lines and in vivo models of primary/metastatic SCLC

B., Jones, D