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Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

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However, in 2001, a handful of groundbreaking research discoveries confirmed that the Ca 2+ ionophore ionomycin could trigger an apoptosis-like cell death in erythrocytes associated with the appearance of apoptotic signs, including cell shrinkage, membrane vesiculation, or PS exposure [22, 23]

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Mouse experimentation and breeding were done in a SPF-facility at 2024 C, 5070% humidity, and a light-dark cycle of 12 h