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Table 3 Antioxidants and their supplementation in allergic diseases

A small clinical study with 20 healthy volunteers demonstrated that Pycnogenol intake for four weeks increased gene expression of hyaluronic acid synthase by 44% (25)

Moreover, embedding bioactive compounds such as polyphenols or flavonoids enhances the antioxidant capacity of HA, enabling more effective scavenging of ROS and mitigating oxidative damage in plants

We evaluated the therapeutic efficacy of the natural bioactives aescin and rutin, alone and in combination with PTU, in L-thyroxineinduced hyperthyroid rats

Studies indicate that its methanolic root extract can influence dopaminergic neurons through GABA-A receptors [232]