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Interestingly, the antinociceptive effect of dalargin was even more pronounced for PBCA nanoparticles precoated with PS80 and overcoated with ApoB and ApoE

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Calcium-dependent glutamate cytotoxicity in a neuronal cell line

There is a piece of evidence that continuous infusion of AMPA in the lumbar spinal cord of adult rats resulted in excessive activation of Ca 2+ -permeable AMPARs (CP-AMPARs), leading to progressive hindlimb paralysis and bilateral motor neuron (MN) degeneration [52]