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P., Hawkins, T., Hussey, P

Introduction Pulmonary fibrosis (PF) is a chronic, progressive, and fatal interstitial lung disease (ILD) associated with loss of alveolar gas exchange function and excessive deposition of extracellular matrix (ECM) [1], leading to irreversible progressive lung scar formation

Among them, MMP1 is more common in alveolar macrophages and epithelial cells, while TIMP is highly expressed by myofibroblasts in IPF fibroblastic foci (Zolak and de Andrade, 2012)

J Bacteriol 186:31243132

Discard the vial and reconstitute a new one

The role appears to be partially mediated through the recruitment of fibroblasts