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The metabolic benefits appear to result from multiple mechanisms, including enhanced mitochondrial function, improved insulin signaling, and activation of metabolic regulatory pathways controlled by sirtuins

In this case, inhibition rather than activation of this protein reduced colonic mucosal immune activation

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Null mutations in Mc4r cause pronounced, dominantly inherited, monogenic obesity in rodents and humans, and are associated with increased food intake, decreased energy expenditure, and increased lean body and fat mass [56,57]

Tapia, EM