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Methylene blue is not a new substance, as it was the first pharmaceutical ever prescribed in the United States in the late 1800s, and it has traditionally been used to treat carbon monoxide poisoning 1h45m1s

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Lucena-Cacace A, Umeda M, Navas LE, Carnero A

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The absence of tissue growth effects also means AOD-9604 avoids many common side effects of growth hormone therapy including joint pain and swelling from connective tissue proliferation, carpal tunnel syndrome from tissue expansion, edema and fluid retention from protein synthesis and sodium retention, and concerns about growth-promoting effects in individuals with tumor history