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Description
These amenable properties demonstrated for the small molecules led us to conduct a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects
Additionally, NR treatment led to improved health and lifespan in the same animal models 111,288
doi: 10.1182/blood-2017-03-770776 11 WangH-FNingFLiuZ-CWuLLiZ-QQiY-Fet al
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