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2022;23(11):1826 e1821-1826 e1835

We hypothesize that excessive intake of folic acid depletes serum holotranscobalamin (holoTC), thereby decreasing active vitamin B-12 in the circulation and limiting its availability for tissues

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the Cochrane review cited further down offers an independent perspective.) A large German observational cohort of 3,602 infertile women with PCOS reported that 70% restored ovulation during 23 months of treatment with myo-inositol 4 g daily plus folic acid, with a 15.1% pregnancy rate over the observation period

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While collagen is essential to tissue healing and wound repair, excessive or disordered collagen deposition can lead to a host of problems including hypertrophic scar formation