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Description
This cascade stimulates downstream transcription factors, most notably cAMP response element-binding protein (CREB), which modulates the transcription of anti-inflammatory cytokines (e.g., IL-10), neurotrophic factors (e.g., BDNF), and genes involved in circadian entrainment
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MOTS-c activates AMPK, one of the same pathways exercise activates, which earned it the exercise mimetic label
10.1039/C8FO01914B 108
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