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A similar metabolic mode of negative regulation of NLRP3 inflammasomes occurs via nitric oxide [118,119,120] generated downstream of pro-inflammatory stimulus-mediated transcription of the nitric oxide synthase 2 gene or inducible nitric oxide synthase (iNOS)

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Self-DNA from dying infected endothelial cells that have been engulfed by macrophages can activate TLR9 in these cells to trigger NF-B-controlled inflammatory signalling

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