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In the open field test conducted on the following day, KI mice also displayed a pronounced anxiety-like phenotype, as reflected by reduced center time and fewer center entries, without differences in total distance traveled between genotypes, indicating that these effects were not attributable to altered locomotor activity (Additional file 1: Fig

Delay age-related cognitive decline

The conjugates/products of phase II reactions are absolutely free of pharmacological activity

Meanwhile, research using human brain organoid models has demonstrated that ferroptosis inhibitors (Ferrostatin-1) can block A pathology, reduce lipid peroxidation and restore iron storage function in AD organoids (86)

Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS, et al

56 It was confirmed that the aggregation of neutrophils and macrophages in the injured area was necessary to promote liver regeneration