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Implications and Recommendations for Future Studies As summarized in this review, NNMT plays important roles in obesity and T2D and is an attractive therapeutic target to prevent or treat obesity and associated T2D
Key Areas of Study NNMT inhibition research adipocyte metabolism studies NAD+ salvage pathway analysis metabolic enzyme targeting investigations Mechanisms Being Evaluated By inhibiting NNMT, 5-Amino-1MQ has been shown to increase intracellular NAD+ and S-adenosyl methionine (SAM) concentrations in preclinical models
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