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While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers

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First , sermorelin is not FDA-approved for metabolic or weight management indications, and its use in these contexts remains off-label with limited evidence quality

SS-31, a mitochondria-targeting peptide, addresses the energy deficit that underlies much neurodegenerative pathology