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Mechanistically, RSPO2 inhibits PI3K-AKT-eNOS signalling via LGR4

Chaperone-like activity of OsDHAR In our lab, we found that OsDHAR exhibited both DHAR and chaperone-like activity in vitro

MOTS-c treatment significantly (i) improves physical performance in young, middle-age, and old mice, (ii) regulates skeletal muscle metabolism and gene expression, and (iii) enhances adaptation to metabolic stress in C2C12 cells in an HSF1-dependent manner

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Age-related decline support: Many connective tissue issues worsen with age because regenerative signaling declines

Without multi-generational reproductive toxicity studies, we cannot confirm whether BPC-157 affects: Sperm motility, morphology, or DNA integrity in male reproductive systems Ovarian follicle maturation or oocyte quality Implantation success rates or early embryonic viability Placental architecture or foetal growth restriction Postnatal development or behavioural outcomes in offspring These gaps matter because peptides with angiogenic mechanisms have shown reproductive effects in other contexts