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This study used the NNMTi 5-amino-1-methylquinolinium (5A-M1Q), since our lab has set precedence using this probe molecule for proof-of-concept studies 8
162,163,164 Exa-cel (Casgevy) was approved in November 2023 as the first gene-editing therapeutic drug based on the CRISPR/Cas9 system for treating sickle cell disease (SCD) and transfusion-dependent -thalassemia (TDT)

Olson, 1988

JAMA Dermatol 150(1):4750

Oxidative Stress and Inflammation Inflammatory responses generate oxidative stress and lower cellular antioxidant capability