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In DOR, elevated ROS expression, largely mediated by NF-B activation, directly impairs mitochondrial function in oocytes, induces granulosa cell apoptosis, accelerates follicular atresia, and promotes depletion of the ovarian reserve [33, 39,40,41]

Health consequences of iodine deficiency

However, existing basic research is sketchy in screening miRNA targets and lacks strong experimental validation

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This can improve drug stability and drug bioavailability, maintain drug concentration in plasma, and reduce drug toxicity

This review paper describes the anatomical, histological and physiological basis and summarises currently approved drugs for administration via intranasal delivery