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The results are shown diagrammatically in Figure 1

In anterograde regulation, proteins encoded by the nuclear genome are transferred to the mitochondria to perform functions (71), while in retrograde regulation, the signal generated from mitochondria passes into the nucleus to induce gene expression, which occurs when mitochondrial homeostasis is interrupted by hypoxia or mutation in mtDNA, or mitochondrial Ca 2+ release (72, 73)

We also reached out to experts in the field and used the World Health Organization International Clinical Trials Registry Platform ( and to find active trials

Idiosyncratic DILI is a severe liver injury occurring very rarely and usually is not dose-dependent

To transport fatty acids into the mitochondria, the powerhouse of the cell, where these fats are then burned to produce energy

Methods 40 , 3945 (1998)