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A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

[DOI] [PubMed] [Google Scholar] 27.Vitamin B12 status in metformin treated patients: systematic review

Cross-linking Protein cross-linking can be used to overcome the issue of the antibody fragments eluting with the protein of interest when using Protein A, G or A/G
Improved Mood : Low levels of Vitamin B12 have been linked to mood disturbances such as depression and anxiety

May 2021;278(5):1693-1698
