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Cytotoxic Chemotherapy Agents (HCPCS J-Codes) Immunotherapy & Biologic Agents Endocrine / Hormonal Therapy Agents Coder Note: Adverse Effect Coding T45.1X5A When a patient develops a complication (nausea, neutropenia, neuropathy, stomatitis, cardiotoxicity) as a result of correctly prescribed and properly administered antineoplastic chemotherapy, the appropriate adverse effect code is T45.1X5A (adverse effect of antineoplastic and immunosuppressive drugs, initial encounter) per FY2026 ICD-10-CM Table of Drugs and Chemicals

## **J1561 documentation requirements** For HCPCS code J1561, records must support medical necessity and include the patients diagnosis, dosage (liquid 500 mg units), method of administration, and date of service