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One type of MDR is based on overexpression of efflux pumps at the plasma membrane, such as P-gp, MRP1, and BCRP, resulting in strongly reduced intracellular drug concentrations [12]

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Poliovirus infection causes an asymmetric flaccid paralysis due to the destruction of anterior horn cells, typically accompanied by a viral prodrome of fever, malaise, and aseptic meningitis

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H., Thrasher, J

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