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187 , 188 ISB 1342, a bispecific Tcell engager antibody binding to a different CD38 epitope is currently in Phase 1 studies, and has been shown to elicit potent antitumor activity in samples from RRMM patients who have previously received daratumumab

Cellular viability Optimization of Sp concentration and its cytotoxicity parameters were established by treating of 1.5 10 5 HeLa or 1.2 10 5 SHSY-5Y cells with serial concentrations of the Sp (100 M1 mM) for 15 min or conducting a time-course (5 min48 h) using 250 M Sp, followed by MTT assay as per standard protocol (Thermo Fisher Scientific)

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