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For example, an inflammatory response induces changes in expression and activity of multidrug-resistance (MDR)-associated protein transporters, greatly affecting drug responses [243, 244]

however, after activation in the inner membrane space of mitochondria, it enhances the transfer of electrons from cytochrome C to oxygen with the formation of mitochondrial ROS (Figure 9) [356,357]

autoimmune Enceph

Inactive form
For example, Campisi et al
