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this results in reduced transcription of mitochondrial ribosomal proteins and mitochondrial transcription factors, and subsequently halting protein translation 101,102

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For individuals with the GG genotype, practical support may include emphasizing protein-rich meals, high-fiber carbohydrates, consistent meal timing, regular exercise, restorative sleep, and minimizing ultra-processed foods that can worsen appetite dysregulation

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During semaglutide therapy, patients with a history of diabetic retinopathy should be closely monitored

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