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Description
In laboratory animals, the forced overexpression of the TKT gene promotes the development of MAFLD as well as the advancement of MAFLD to the more severe state referred to as metabolic dysfunction-associated steatohepatitis (MASH)

Multiple studies show significant body weight reduction and improved body composition

A nasal spray must penetrate nasal mucosa, possibly deal with mucociliary clearance, and may have somewhat reduced bioavailability

It has been shown that the AMPK-PGC1a axis plays an important role in joint inflammation, and the exosome miR130b3p regulates mitochondrial function and exacerbates cartilage damage by targeting the AMPK-PGC1a axis (43)

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Compounds with lower pKa values act as stronger acids, making them more soluble in water and reducing LogP
