glutathione synthase definition (GSH) is synthesized in the cytoplasm by the action of Glutathione

Notably, these pathological alternations and reductive stress were significantly normalized by replacing the wild-type G6PD with a hypomorphic G6PD mutant in the R120G mice (77), suggesting that the G6PD-mediated reductive stress contributes to the development of this disease

Step 4: Vitamin C goes back to work

Peer review Peer review information Communications Biology thanks Yoshitaka Isaka and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

If it stays elevated, the cause lies elsewhere and needs proper investigation

10.1016/J.TOXLET.2006.07.340 [DOI] [PubMed] [Google Scholar] Zhao H, Wu H, He J et al (2016) Frontal cortical mitochondrial dysfunction and mitochondria-related -amyloid accumulation by chronic sleep restriction in mice

editor Folate in health and disease