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Nitric oxide serves multiple functions in wound healing: it promotes vasodilation (widening of blood vessels), supports endothelial cell proliferation, and helps regulate the inflammatory response

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The composition of the simulated systems is detailed in Supplementary Table S10

DSIP has been studied in controlled clinical settings for its ability to increase sleep duration, improve sleep architecture, and support restorative sleep patterns in both healthy subjects and individuals with disrupted sleep

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