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This controlled mitochondrial handling of Ca 2+ supports metabolic output and enables soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) and their proteins (syntaxin-2/11, SNAP-23, VAMP-7/8) mediated graded -granule exocytosis necessary for platelet plug stabilization without producing excess thrombus (Pokrovskaya et al., 2018)

That can mean more frequent colds, longer recovery times, recurring infections, and even an increased susceptibility to inflammatory or autoimmune conditions

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