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Importantly, hepatic gluconeogenesis produces glucose-6-phosphate, which together with that produced from glycogen degradation (glycogenolysis) must be hydrolyzed by glucose-6-phosphatase in the endoplasmic reticulum to be released as glucose into the circulation (Cahill et al., 1959)

in Chronic Complications of Diabetes Mellitus (Galloway, D.M

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Aging causes hormone levels to decline and subsequently the body does not function at its best

Jenner et al., 1984)
