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Sustained pro-inflammatory cytokine production In progressive MS there is increased microglia and macrophages reactivity into a pro-inflammatory phenotype, which may contribute to neurodegeneration via a number of potential mechanisms

Antiproliferative effects of Se may not be limited to the accumulation of harmful Se-metabolites

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doi: 10.1016/S0378-4274(02)00470-8

77,78 Pentoxifylline has been shown to decrease malondialdehyde concentration, increase the GSH:GSSG ratio, and enhance the expression of Nrf2, a key regulator of cellular oxidative stress, further validating its antioxidant properties