gsh gold glutathione Illustration of MTX/Au-GSH-FA NP structure. Au—gold, GSH—glutathione, How Glutathione Works in the

| Dowd, CA., et al

HDACs are classified into four categories: classes I, II, and IV HDACs are Zn 2+ -dependent enzymes, whereas class III HDACs are NAD + -dependent deacetylases (Hyndman, 2020)

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These enzymes are categorized into cytosolic, mitochondrial, and microsomal members and are classified into multiple classes including Alpha (A), Mu (M), and Pi (P), each with distinct subtypes

Other reported changes from MedDiet in gut microbiota include augmentation of Bacteroides, Lactobacilli, Bifidobacteria, Oscillospira, Roseburia, Clostridium cluster XIVa along with a reduction in Firmicutes and Proteobacteria phyla [286]

doi: 10.1007/s00709-019-01368-0