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By interacting directly with MAPKs, including c-Jun N-terminal kinase 1 (JNK1) and apoptosis signal-regulating kinase 1 (ASK1), GSTs bind the ligand in a complex structure, preventing interactions with their downstream targets [74]

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This code applies when B12 deficiency results from causes like gastric bypass surgery, Crohns disease affecting the terminal ileum, or medication interference (metformin, proton pump inhibitors)