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Description

Sphingolipids includes sphingosine 1-phosphate (S1P), ceramide, glucosylceramide (GlcCer) and sphingosine that regulates various biological events such as proliferation, apoptosis, inflammation, senescence and cell migration in cancer cells [133,134]

The immunoblots were visualized using ECL Western blotting substrate (Pierce Biotechnology) on a Chemidoc XRS imager (Bio Rad) or using Dylight 800-conjugated secondary antibodies (Thermo Fisher Scientific, Rockford, IL) on an Odyssey Imaging Systems (LI-COR Biosciences, Lincoln, NE)

This protects cells from oxidative damage while reducing the inflammatory burden

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