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A Phase I safety trial evaluating the administration of synthetic T4 at massive doses ranging from 42mg to 1260mg over 14 days demonstrated excellent tolerability with no severe toxicities or serious adverse events reported in healthy adults

However, these findings represent associative correlations rather than direct mechanistic proof

It has been proposed that the binding of HGF to c-MET induces the dimerization of c-MET that enables its intracellular kinase domains (KDs) to undergo autophosphorylation 7

"Using peptide and regenerative therapies, we can heal the muscle damage and metabolic/oxidative stress more rapidly, thus increasing muscle gains while inhibiting muscle loss

doi: 10.1046/j.1523-1747.1999.00633.x