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FIGURE 2 3.2 Inflammatory pathway activation via mtROS and mtDNA leakage 3.2.1 mtROS and the NLRP3 inflammasome mtROS is a potent activator of the NLRP3 inflammasome, a multiprotein platform composed of NLRP3, ASC, and caspase-1 (Jang et al., 2015

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[DOI] [Google Scholar] 49.Hou J., Sun Q., Li J., Ahammed G.J., Yu J., Fang H., Xia X

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