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The role of miR- 138-5p in inhibiting autophagy within PC cells by binding to SIRT1, which regulates autophagy through the FoxO1/Rab7 axis, has been explored

I.L.s research is supported by the NIH grants 2R01AG038791-06A, U01NS100610, U01NS80818, R25NS098999, U19 AG063911-1 and 1R21NS114764-01A1, the Michael J Fox Foundation, Parkinson Foundation, Lewy Body Association, CurePSP, Abbvie, Biogen, Biohaven Pharmaceuticals, Brain Neurotherapy Bio, Centogene, EIP Pharma, Novartis, Roche, United Biopharma and UCB

Y., Wang, J

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Glutathione concentrations in the brain decline with age, and this decline has been associated with increased vulnerability to neurodegenerative processes

Clinical trial data from over 11,000 participants demonstrates that these symptoms are predominantly mild-to-moderate in severity, with 98% classified as mild or moderate and 99.5% being non-serious